In December 1947, three physicists at Bell Telephone Laboratories—John Bardeen, William Shockley, and Walter Brattain—built a compact electronic device using thin gold wires and a piece of germanium, a material known as a semiconductor. Their invention, later named the transistor (for which they were awarded the Nobel Prize in 1956), could amplify and switch electrical signals, marking a dramatic departure from the bulky and fragile vacuum tubes that had powered electronics until then.

Its inventors weren’t chasing a specific product. They were asking fundamental questions about how electrons behave in semiconductors, experimenting with surface states and electron mobility in germanium crystals. Over months of trial and refinement, they combined theoretical insights from quantum mechanics with hands-on experimentation in solid-state physics—work many might have dismissed as too basic, academic, or unprofitable.

Their efforts culminated in a moment that now marks the dawn of the information age. Transistors don’t usually get the credit they deserve, yet they are the bedrock of every smartphone, computer, satellite, MRI scanner, GPS system, and artificial-intelligence platform we use today. With their ability to modulate (and route) electrical current at astonishing speeds, transistors make modern and future computing and electronics possible.

This breakthrough did not emerge from a business plan or product pitch. It arose from open-ended, curiosity-driven research and enabling development, supported by an institution that saw value in exploring the unknown. It took years of trial and error, collaborations across disciplines, and a deep belief that understanding nature—even without a guaranteed payoff—was worth the effort.

After the first successful demonstration in late 1947, the invention of the transistor remained confidential while Bell Labs filed patent applications and continued development. It was publicly announced at a press conference on June 30, 1948, in New York City. The scientific explanation followed in a seminal paper published in the journal Physical Review

How do they work? At their core, transistors are made of semiconductors—materials like germanium and, later, silicon—that can either conduct or resist electricity depending on subtle manipulations of their structure and charge. In a typical transistor, a small voltage applied to one part of the device (the gate) either allows or blocks the electric current flowing through another part (the channel). It’s this simple control mechanism, scaled up billions of times, that lets your phone run apps, your laptop render images, and your search engine return answers in milliseconds.

Though early devices used germanium, researchers soon discovered that silicon—more thermally stable, moisture resistant, and far more abundant—was better suited for industrial production. By the late 1950s, the transition to silicon was underway, making possible the development of integrated circuits and, eventually, the microprocessors that power today’s digital world.

A modern chip the size of a human fingernail now contains tens of billions of silicon transistors, each measured in nanometers—smaller than many viruses. These tiny switches turn on and off billions of times per second, controlling the flow of electrical signals involved in computation, data storage, audio and visual processing, and artificial intelligence. They form the fundamental infrastructure behind nearly every digital device in use today. 

The global semiconductor industry is now worth over half a trillion dollars. Devices that began as experimental prototypes in a physics lab now underpin economies, national security, health care, education, and global communication. But the transistor’s origin story carries a deeper lesson—one we risk forgetting.

Much of the fundamental understanding that moved transistor technology forward came from federally funded university research. Nearly a quarter of transistor research at Bell Labs in the 1950s was supported by the federal government. Much of the rest was subsidized by revenue from AT&T’s monopoly on the US phone system, which flowed into industrial R&D.

Inspired by the 1945 report “Science: The Endless Frontier,” authored by Vannevar Bush at the request of President Truman, the US government began a long-standing tradition of investing in basic research. These investments have paid steady dividends across many scientific domains—from nuclear energy to lasers, and from medical technologies to artificial intelligence. Trained in fundamental research, generations of students have emerged from university labs with the knowledge and skills necessary to push existing technology beyond its known capabilities.

And yet, funding for basic science—and for the education of those who can pursue it—is under increasing pressure. The new White House’s proposed federal budget includes deep cuts to the Department of Energy and the National Science Foundation (though Congress may deviate from those recommendations). Already, the National Institutes of Health has canceled or paused more than $1.9 billion in grants, while NSF STEM education programs suffered more than $700 million in terminations.

These losses have forced some universities to freeze graduate student admissions, cancel internships, and scale back summer research opportunities—making it harder for young people to pursue scientific and engineering careers. In an age dominated by short-term metrics and rapid returns, it can be difficult to justify research whose applications may not materialize for decades. But those are precisely the kinds of efforts we must support if we want to secure our technological future.

Consider John McCarthy, the mathematician and computer scientist who coined the term “artificial intelligence.” In the late 1950s, while at MIT, he led one of the first AI groups and developed Lisp, a programming language still used today in scientific computing and AI applications. At the time, practical AI seemed far off. But that early foundational work laid the groundwork for today’s AI-driven world.

After the initial enthusiasm of the 1950s through the ’70s, interest in neural networks—a leading AI architecture today inspired by the human brain—declined during the so-called “AI winters” of the late 1990s and early 2000s. Limited data, inadequate computational power, and theoretical gaps made it hard for the field to progress. Still, researchers like Geoffrey Hinton and John Hopfield pressed on. Hopfield, now a 2024 Nobel laureate in physics, first introduced his groundbreaking neural network model in 1982, in a paper published in Proceedings of the National Academy of Sciences of the USA. His work revealed the deep connections between collective computation and the behavior of disordered magnetic systems. Together with the work of colleagues including Hinton, who was awarded the Nobel the same year, this foundational research seeded the explosion of deep-learning technologies we see today.

One reason neural networks now flourish is the graphics processing unit, or GPU—originally designed for gaming but now essential for the matrix-heavy operations of AI. These chips themselves rely on decades of fundamental research in materials science and solid-state physics: high-dielectric materials, strained silicon alloys, and other advances making it possible to produce the most efficient transistors possible. We are now entering another frontier, exploring memristors, phase-changing and 2D materials, and spintronic devices.

If you’re reading this on a phone or laptop, you’re holding the result of a gamble someone once made on curiosity. That same curiosity is still alive in university and research labs today—in often unglamorous, sometimes obscure work quietly laying the groundwork for revolutions that will infiltrate some of the most essential aspects of our lives 50 years from now. At the leading physics journal where I am editor, my collaborators and I see the painstaking work and dedication behind every paper we handle. Our modern economy—with giants like Nvidia, Microsoft, Apple, Amazon, and Alphabet—would be unimaginable without the humble transistor and the passion for knowledge fueling the relentless curiosity of scientists like those who made it possible.

The next transistor may not look like a switch at all. It might emerge from new kinds of materials (such as quantum, hybrid organic-inorganic, or hierarchical types) or from tools we haven’t yet imagined. But it will need the same ingredients: solid fundamental knowledge, resources, and freedom to pursue open questions driven by curiosity, collaboration—and most importantly, financial support from someone who believes it’s worth the risk.

Julia R. Greer is a materials scientist at the California Institute of Technology. She is a judge for MIT Technology Review’s Innovators Under 35 and a former honoree (in 2008).

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Sneha Goenka is one of MIT Technology Review’s 2025 Innovators Under 35. Meet the rest of this year’s honorees. 

Up to a quarter of children entering intensive care have undiagnosed genetic conditions. To be treated properly, they must first get diagnoses—which means having their genomes sequenced. This process typically takes up to seven weeks. Sadly, that’s often too slow to save a critically ill child.

Hospitals may soon have a faster option, thanks to a groundbreaking system built in part by Sneha Goenka, an assistant professor of electrical and computer engineering at Princeton—and MIT Technology Review’s 2025 Innovator of the Year. 

Five years ago, Goenka and her colleagues designed a rapid-sequencing pipeline that can provide a genetic diagnosis in less than eight hours. Goenka’s software computations and hardware architectures were critical to speeding up each stage of the process. 

“Her work made everyone realize that genome sequencing is not only for research and medical application in the future but can have immediate impact on patient care,” says Jeroen de Ridder, a professor at UMC Utrecht in the Netherlands, who has developed an ultrafast sequencing tool for cancer diagnosis. 

Now, as cofounder and scientific lead of a new company, she is working to make that technology widely available to patients around the world.

Goenka grew up in Mumbai, India. Her mother was an advocate for women’s education, but as a child, Goenka had to fight to persuade other family members to let her continue her studies. She moved away from home at 15 to attend her final two years of school and enroll in a premier test-­preparation academy in Kota, Rajasthan. Thanks to that education, she passed what she describes as “one of the most competitive exams in the world,” to get into the Indian Institute of Technology Bombay. 

Once admitted to a combined bachelor’s and master’s program in electrical engineering, she found that “it was a real boys’ club.” But Goenka excelled in developing computer architecture systems that accelerate computation. As an undergraduate, she began applying those skills to medicine, driven by her desire to “have real-world impact”—in part because she had seen her family struggle with painful uncertainty after her brother was born prematurely when she was eight years old. 

While working on a PhD in electrical engineering at Stanford, she turned her focus to evolutionary and clinical genomics. One day a senior colleague, Euan Ashley, presented her with a problem. He said, “We want to see how fast we can make a genetic diagnosis. If you had unlimited funds and resources, just how fast do you think you could make the compute?”

Streaming DNA

A genetic diagnosis starts with a blood sample, which is prepped to extract the DNA—a process that takes about three hours. Next that DNA needs to be “read.” One of the world’s leading long-read sequencing technologies, developed by Oxford Nanopore Technologies, can generate highly detailed raw data of an individual’s genetic code in about an hour and a half. Unfortunately, processing all this data to identify mutations can take another 21 hours. Shipping samples to a central lab and figuring out which mutations are of interest often leads the process to stretch out to weeks. 

Goenka saw a better way: Build a real-time system that could “stream” the sequencing data, analyzing it as it was being generated, like streaming a film on Netflix rather than downloading it to watch later.

Sneha Goenka

To do this, she designed a cloud computing architecture to pull in more processing power. Goenka’s first challenge was to increase the speed at which her team could upload the raw data for processing, by streamlining the requests between the sequencer and the cloud to avoid unnecessary “chatter.” She worked out the exact number of communication channels needed—and created algorithms that allowed those channels to be reused in the most efficient way.

The next challenge was “base calling”—converting the raw signal from the sequencing machine into the nucleotide bases A, C, T, and G, the language that makes up our DNA. Rather than using a central node to orchestrate this process, which is an inefficient, error-prone approach, Goenka wrote software to automatically assign dozens of data streams directly from the sequencer to dedicated nodes in the cloud.

Meet the rest of this year’s 
Innovators Under 35.

Then, to identify mutations, the sequences were aligned for comparison with a reference genome. She coded a custom program that triggers alignment as soon as base calling finishes for one batch of sequences while simultaneously initiating base calling for the next batch, thus ensuring that the system’s computational resources are used efficiently.

Add all these im­­prove­­ments together, and Goenka’s approach reduced the total time required to analyze a genome for mutations from around 20 hours to 1.5 hours. Finally, the team worked with genetic counselors and physicians to create a filter that identified which mutations were most critical to a person’s health, and that set was then given a final manual curation by a genetic specialist. These final stages take up to three hours. The technology was close to being fully operational when, suddenly, the first patient arrived. 

A critical test

When 13-year-old Matthew was flown to Stanford’s children’s hospital in 2021, he was struggling to breathe and his heart was failing. Doctors needed to know whether the inflammation in his heart was due to a virus or to a genetic mutation that would necessitate a transplant.  

His blood was drawn on a Thursday. The transplant committee made its decisions on Fridays. “It meant we had a small window of time,” says Goenka.

Goenka was in Mumbai when the sequencing began. She stayed up all night, monitoring the computations. That was when the project stopped being about getting faster for the sake of it, she says: “It became about ‘How fast can we get this result to save this person’s life?’”

The results revealed a genetic mutation that explained Matthew’s condition, and he was placed on the transplant list the next day. Three weeks later, he received a new heart. “He’s doing great now,” Goenka says.

So far, Goenka’s technology has been tested on 26 patients, including Matthew. Her pipeline is “directly affecting the medical care of newborns in the Stanford intensive care units,” Ashley says.

Now she’s aiming for even broader impact—Goenka and her colleagues are laying the groundwork for a startup that they hope will bring the technology to market and make sure it reaches as many patients as possible. Meanwhile, she has been refining the computational pipeline, reducing the time to diagnosis to about six hours.

The demand is clear, she says: “In an in-depth study involving more than a dozen laboratory directors and neonatologists, every respondent stressed urgency. One director put it succinctly: ‘I need this platform today—preferably yesterday.’”

Goenka is also developing software to make the technology more inclusive. The reference genome is skewed toward people of European descent. The Human Pangenome Project is an international collaboration to create reference genomes from more diverse populations, which Goenka aims to use to personalize her team’s filters, allowing them to flag mutations that may be more prevalent in the population to which a patient belongs.

Since seeing her work, Goenka’s extended family has become more appreciative of her education and career. “The entire family is very proud about the impact I’ve made,” she says. 

Helen Thomson is a freelance science journalist based in London.

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Iwnetim Abate is one of MIT Technology Review’s 2025 Innovators Under 35. Meet the rest of this year’s honorees. 

“I’m the only one who wears glasses and has eye problems in the family,” Iwnetim Abate says with a smile as sun streams in through the windows of his MIT office. “I think it’s because of the candles.”

In the small town in Ethiopia where he grew up, Abate’s family had electricity, but it was unreliable. So, for several days each week when they were without power, Abate would finish his homework by candlelight.

Today, Abate, 32, is an assistant professor at MIT in the department of materials science and engineering. Part of his research focuses on sodium-ion batteries, which could be cheaper than the lithium-based ones that typically power electric vehicles and grid installations. He’s also pursuing a new research path, examining how to harness the heat and pressure under the Earth’s surface to make ammonia, a chemical used in fertilizer and as a green fuel.

Growing up without the ubiquitous access to electricity that many people take for granted shaped the way Abate thinks about energy issues, he says. He recalls rushing to dry out his school uniform over a fire before he left in the morning. One of his chores was preparing cow dung to burn as fuel—the key is strategically placing holes to ensure proper drying, he says.

Abate’s desire to devote his attention to energy crystallized in a high school chemistry class on fuel cells. “It was like magic,” he says, to learn it’s possible to basically convert water into energy. “Sometimes science is magic, right?”

Abate scored the highest of any student in Ethiopia on the national exam the year he took it, and he knew he wanted to go to the US to further his education. But actually getting there proved to be a challenge. 

Abate applied to US colleges for three years before he was granted admission to Concordia College Moorhead, a small liberal arts college, with a partial scholarship. To raise the remaining money, he reached out to various companies and wealthy people across Ethiopia. He received countless rejections but didn’t let that phase him. He laughs recalling how guards would chase him off when he dropped by prospects’ homes in person. Eventually, a family friend agreed to help.

When Abate finally made it to the Minnesota college, he walked into a room in his dorm building and the lights turned on automatically. “I both felt happy to have all this privilege and I felt guilty at the same time,” he says.

Lab notes

His college wasn’t a research institute, so Abate quickly set out to get into a laboratory. He reached out to Sossina Haile, then at the California Institute of Technology, to ask about a summer research position.

Haile, now at Northwestern University, recalls thinking that Abate was particularly eager. As a visible Ethiopian scientist, she gets a lot of email requests, but his stood out. “No obstacle was going to stand in his way,” she says. It was risky to take on a young student with no research experience who’d only been in the US for a year, but she offered him a spot in her lab.

Abate spent the summer working on materials for use in solid oxide fuel cells. He returned for the following summer, then held a string of positions in energy-materials research, including at IBM and Los Alamos National Lab, before completing his graduate degree at Stanford and postdoctoral work at the University of California, Berkeley.

Meet the rest of this year’s 
Innovators Under 35.

He joined the MIT faculty in 2023 and set out to build a research group of his own. Today, there are two major focuses of his lab. One is sodium-ion batteries, which are a popular alternative to the lithium-based cells used in EVs and grid storage installations. Sodium-ion batteries don’t require the kinds of critical minerals lithium-ion batteries do, which can be both expensive and tied up by geopolitics.  

One major stumbling block for sodium-ion batteries is their energy density. It’s possible to improve energy density by operating at higher voltages, but some of the materials used tend to degrade quickly at high voltages. That limits the total energy density of the battery, so it’s a problem for applications like electric vehicles, where a low energy density would restrict range.

Abate’s team is developing materials that could extend the lifetime of sodium-ion batteries while avoiding the need for nickel, which is considered a critical mineral in the US. The team is examining additives and testing materials-engineering techniques to help the batteries compete with lithium-ion cells.

Irons in the fire

Another vein of Abate’s work is in some ways a departure from his history in batteries and fuel cells. In January, his team published research describing a process to make ammonia underground, using naturally-occurring heat and pressure to drive the necessary chemical reactions.  

Today, making ammonia generates between 1% and 2% of global greenhouse gas emissions. It’s primarily used to fertilize crops, but it’s also being considered as a fuel for sectors like long-distance shipping.

Abate cofounded a company called Addis Energy to commercialize the research, alongside MIT serial entrepreneur Yet-Ming Chiang and a pair of oil industry experts. (Addis means “new” in Amharic, the official language of Ethiopia.) For an upcoming pilot, the company aims to build an underground reactor that can produce ammonia. 

When he’s not tied up in research or the new startup, Abate runs programs for African students. In 2017, he cofounded an organization called Scifro, which runs summer school programs in Ethiopia and plans to expand to other countries, including Rwanda. The programs focus on providing mentorship and educating students about energy and medical devices, which is the specialty of his cofounder. 

While Abate holds a position at one of the world’s most prestigious universities and serves as chief science officer of a buzzy startup, he’s quick to give credit to those around him. “It takes a village to build something, and it’s not just me,” he says.

Abate often thinks about his friends, family, and former neighbors in Ethiopia as he works on new energy solutions. “Of course, science is beautiful, and we want to make an impact,” he says. “Being good at what you do is important, but ultimately, it’s about people.”

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