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What seemed so impossible at the beginning of the pandemic is now real: vaccines are here, in record time. They bring much-needed hope to a holiday season shadowed by death and fear.

While authorities work out details for this mass vaccination campaign, though, the public is still waiting for answers to fundamental questions. Who gets the vaccine? Who will know if we’ve gotten it? Will workplaces, schools, or governments demand to see our vaccine records before letting us in? 

You may have heard about using “vaccine certification” or “immunity passports,” analog or digital tools to prove you’re vaccinated. Some experts champion them as a way to get back to normal life, while others warn about privacy risks and the potential for discrimination and abuse. 

These debates are mostly speculative, but underlying issues of privacy, verification, and ethical use aren’t unique to the vaccine. Governments and businesses already use covid-related records every day to make decisions about who can do what. Here’s what we know.

Vaccination records aren’t new, but there will be new ways to use them

There’s nothing revolutionary about needing to prove you’ve had a vaccine. Some countries require evidence of a yellow fever shot before you can clear customs, and many schools will not let you enroll your children in school unless they’re up to date on mandatory immunizations. Official tracking of who gets what vaccine is old news too. National and local governments around the world run registries where doctors send their vaccination records. 

But a lot is happening behind the scenes to expand these uses, some of it very quickly. Governments, airlines, employers, universities, and many other groups are intensely debating how and why people will need to show verified health records.

Some of the terms being thrown around are confusing, like “vaccine passport.” In some scenarios, your records might function like an actual passport—think of arriving at the airport in a new country, pulling out your smartphone, and scanning a digital record of your vaccination or negative test. But those records could also act like a work authorization at your job, or a pass to get into restaurants, bars, and shopping malls. 

Proponents argue that digital health credentials could help us get back to “normal,” but there are lots of roadblocks to making these ideas a reality, both on a medical and technical level.

Immunization doesn’t mean safety

While several vaccines appear highly effective at preventing symptoms of covid-19, we don’t know whether they stop people from catching and spreading the virus asymptomatically. Trials of the Oxford-AstraZeneca vaccine suggested it may limit transmission from asymptomatic carriers, but Pfizer and Moderna’s trials didn’t regularly test participants for the virus if they didn’t have symptoms.

More data is needed to prove conclusively that vaccination prevents you from giving covid-19 to other people, and how long immunity lasts. It’s also important to remember that what’s true for one vaccine may not be true for another. 

Without these crucial pieces of information, vaccination credentials only prove that you received a vaccine on a particular date—not that you do not have and cannot catch the disease. In the meantime, a negative covid test remains the best evidence that you’re not contagious. And since tests are far from perfect, you should still follow public health guidance about limiting spread whenever you can.

Digital records help combat fake information

There is already a booming black market in fake test results that is diminishing trust in printed records and driving demand for cheat-proof digital documents. 

Many governments, as well as airlines and other businesses are trialing or in talks to build “health pass” apps, which let users ask participating labs and health systems to send authenticated test results and other data straight to the app, bypassing verification concerns. 

There are a lot of players in the field, including IBM, the Commons Project, and the Covid Credentials Initiative. They’re coming at the problem from different angles but are ultimately chasing the same goal: let people share required information about their health, while protecting other private information. Yet it’s still too early to rely on any of these for a fast and widespread solution. 

Linking up systems is very difficult

Health-pass makers are mostly focused on test results for now, but any of those technologies could work just as well for vaccine records, if all the systems worked together.

Unfortunately, that’s a much bigger challenge than signing deals with a couple of big testing companies. Connecting any systems across borders means navigating a patchwork of languages, databases, and privacy laws. Even in the UK, where the National Health System maintains a database of vaccine recipients, the government has put any talk of vaccine “passports” on hold

Universal vaccine credentials may be close to impossible in the US, where patient data is fragmented across tens of thousands of health-care businesses. Forget digital interoperability standards—a lot of American doctors still rely on fax machines to send records. While most vaccinations are captured in state or local registries, using those databases for digital verification may face both legal and technological barriers.

No one solution will work for everybody

Even if these tools are built, blocking people from ordinary activities on the basis of their vaccination status brings up serious ethical and legal considerations. Screening people by vaccination status is hard when no country has made vaccination mandatory so far, and there are many cases in which people who might otherwise be eligible (for example, pregnant women or those who suffer from serious allergies) are discouraged from receiving the vaccine while more data is gathered.

Some people can’t or don’t want to use smartphones for their medical records, meanwhile. This may be especially true for those hardest hit by the pandemic, including elderly, homeless, and undocumented people. And given the challenges faced even by countries with significant resources, it’s hard to imagine every immunization clinic in the world handing out QR codes with their vaccines. 

Whatever the case, our regular lives are still a long way off

No matter how enthusiastic individuals and businesses are about using vaccination credentials or other verification to return to “normal,” there are many reasons to be skeptical of a high-tech solution. Even if all the necessary layers of digital and analog infrastructure do start talking to one another, we still don’t know whether vaccination keeps people around you safe. 

At this moment, we live in a world with one genuine piece of progress: vaccines created in jaw-dropping time. Vials of it are being packed onto aircraft and trucks that are delivering them to patients around the world. In the meantime, we wait. 

—Additional reporting by Mia Sato.

This story is part of the Pandemic Technology Project, supported by the Rockefeller Foundation.

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When resident physicians at Stanford Medical Center—many of whom work on the front lines of the covid-19 pandemic—found out that only seven out of over 1,300 of them had been prioritized for the first 5,000 doses of the covid vaccine, they were shocked. Then, when they saw who else had made the list, including administrators and doctors seeing patients remotely from home, they were angry.

During a planned photo op to celebrate the first vaccinations taking place on Friday, December 18, at least 100 residents showed up to protest. Hospital leadership apologized for not prioritizing them, and blamed the errors on “a very complex algorithm.” 

“Our algorithm, that the ethicists, infectious disease experts worked on for weeks … clearly didn’t work right,” Tim Morrison, the director of the ambulatory care team, told residents at the event in a video posted online.

Stanford residents protest a photo op to celebrate the arrival of a vaccine.
Stanford residents protest a photo op to celebrate the arrival of a vaccine.
COURTESY OF WILLIAM FITZGERALD

Many saw that as an excuse, especially since hospital leadership had been made aware of the problem on Tuesday—when only five residents made the list—and responded not by fixing the algorithm, but by adding two more residents for a total of seven. 

“One of the core attractions of algorithms is that they allow the powerful to blame a black box for politically unattractive outcomes for which they would otherwise be responsible,” Roger McNamee, a prominent Silicon Valley insider turned critic, wrote on Twitter. “But *people* decided who would get the vaccine,” tweeted Veena Dubal, a professor of law at the University of California, Hastings, who researches technology and society. “The algorithm just carried out their will.”

But what exactly was Stanford’s “will”? We took a look at the algorithm to find out what it was meant to do. 

How the algorithm works

The slide describing the algorithm came from residents who had received it from their department chair. It is not a complex machine-learning algorithm (which are often referred to as “black boxes”) but a rules-based formula for calculating who would get the vaccine first at Stanford. It considers three categories: “employee-based variables,” which have to do with age; “job-based variables”; and guidelines from the California Department of Public Health. For each category, staff received a certain number of points, with a total possible score of 3.48. Presumably, the higher the score, the higher the person’s priority in line. (Stanford Medical Center did not respond to multiple requests for comment on the algorithm over the weekend.) 

The employee variables increase a person’s score linearly with age, and extra points are added to those over 65 or under 25. This gives priority to the oldest and youngest staff, which disadvantages residents and other frontline workers who are typically in the middle of the age range.

Job variables contribute the most to the overall score. The algorithm counts the prevalence of covid-19 among employees’ job roles and department in two different ways, but the difference between them is not entirely clear. Neither the residents nor two unaffiliated experts we asked to review the algorithm understood what these criteria meant, and Stanford Medical Center did not respond to a request for comment. They also consider the proportion of tests taken by job role as a percentage of the medical center’s total number of tests collected. 

What these factors do not take into account is exposure to patients with covid-19, say residents. That means the algorithm did not distinguish between those who had caught covid from patients and those who got it from community spread—including employees working remotely. And, as first reported by ProPublica, residents were told that because they rotate between departments rather than maintain a single assignment, they lost out on points associated with the departments where they worked. 

The algorithm’s third category refers to the California Department of Public Health’s vaccine allocation guidelines. These focus on exposure risk as the single highest factor for vaccine prioritization. The guidelines are intended primarily for county and local governments to decide how to prioritize the vaccine, rather than how to prioritize between a hospital’s departments. But they do specifically include residents, along with the departments where they work, in the highest-priority tier. 

It may be that the “CDPH range” factor gives residents a higher score, but still not high enough to counteract the other criteria.

“Why did they do it that way?” 

Stanford tried to factor in a lot more variables than other medical facilities, but Jeffrey Kahn, the director of the Johns Hopkins Berkman Institute of Bioethics, says the approach was overcomplicated. “The more there are different weights for different things, it then becomes harder to understand—‘Why did they do it that way?’” he says.

Kahn, who sat on Johns Hopkins’ 20-member committee on vaccine allocation, says his university allocated vaccines based simply on job and risk of exposure to covid-19.

He says that decision was based on discussions that purposefully included different perspectives—including those of residents—and in coordination with other hospitals in Maryland. Elsewhere, the University of California San Francisco’s plan is based on a similar assessment of risk of exposure to the virus. Mass General Brigham in Boston categorizes employees into four groups based on department and job location, according to an internal email reviewed by MIT Technology Review.

“There’s so little trust around so much related to the pandemic, we cannot squander it.”

“It’s really important [for] any approach like this to be transparent and public …and not something really hard to figure out,” Kahn says. “There’s so little trust around so much related to the pandemic, we cannot squander it.” 

Algorithms are commonly used in health care to rank patients by risk level in an effort to distribute care and resources more equitably. But the more variables used, the harder it is to assess whether the calculations might be flawed.

For example, in 2019, a study published in Science showed that 10 widely used algorithms for distributing care in the US ended up favoring white patients over Black ones. The problem, it turned out, was that the algorithms’ designers assumed that patients who spent more on health care were more sickly and needed more help. In reality, higher spenders are also richer, and more likely to be white. As a result, the algorithm allocated less care to Black patients with the same medical conditions as white ones.

Irene Chen, an MIT doctoral candidate who studies the use of fair algorithms in health care, suspects this is what happened at Stanford: the formula’s designers chose variables that they believed would serve as good proxies for a given staffer’s level of covid risk. But they didn’t verify that these proxies led to sensible outcomes, or respond in a meaningful way to the community’s input when the vaccine plan came to light on Tuesday last week. “It’s not a bad thing that people had thoughts about it afterward,” says Chen. “It’s that there wasn’t a mechanism to fix it.”

A canary in the coal mine?

After the protests, Stanford issued a formal apology, saying it would revise its distribution plan. 

Hospital representatives did not respond to questions about who they would include in new planning processes, or whether the algorithm would continue to be used. An internal email summarizing the medical school’s response, shared with MIT Technology Review, states that neither program heads, department chairs, attending physicians, nor nursing staff were involved in the original algorithm design. Now, however, some faculty are pushing to have a bigger role, eliminating the algorithms’ results completely and instead giving division chiefs and chairs the authority to make decisions for their own teams. 

Other department chairs have encouraged residents to get vaccinated first. Some have even asked faculty to bring residents with them when they get vaccinated, or delay their shots so that others could go first.

Some residents are bypassing the university health-care system entirely. Nuriel Moghavem, a neurology resident who was the first to publicize the problems at Stanford, tweeted on Friday afternoon that he had finally received his vaccine—not at Stanford, but at a public county hospital in Santa Clara County. 
“I got vaccinated today to protect myself, my family, and my patients,” he tweeted. “But I only had the opportunity because my public county hospital believes that residents are critical front-line providers. Grateful.”

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A rising wave of covid-19 cases in the south of England has been blamed on a new variant of the coronavirus. The new version, which appeared by September, is now behind half the cases in the region. Genomic researchers have found that not only does the variant have a lot of mutations, but several of the genetic alterations are predicted to make possibly significant changes to the spike protein, a part of the virus that plays a key role in infecting cells. 

On Saturday, December 19, UK prime minister Boris Johnson gave a televised press conference in which he announced new restrictions on movement for the Christmas season, and a total lockdown in London and the southeast in response to the sudden spike in cases.

“It seems that the spread is now being driven by the new variant,” Johnson told the public. “It does appear that it is passed on significantly more easily.” 

His experts, Johnson said, had made preliminary calculations that the variant could represent a new strain that is up to 70% more transmissible. The immediate result of the leader’s comments was panic. Although there isn’t evidence the new strain is more deadly, by Sunday a number of European countries—including Italy, Ireland, Germany, France, and the Netherlands—were restricting travel to the UK. The UK-France Eurotunnel closed on Sunday night as France shut its borders to travelers from the UK for 48 hours.

Over the weekend, medical experts sought to reassure the public that the variant virus, named VUI – 202012/01 (for “first variant under investigation in December 2020”), would not affect vaccination efforts, which began in the UK and the US this month. One reason is that the virus would have to change substantially to “escape” the current vaccine. Even if it does, vaccines can be adjusted to keep up with shape-shifting pathogens, as is the case with the annual flu shot. 

On Sunday, US Surgeon General Jerome Adams said on CBS News’s Face the Nation that there are “no indications” the new variant will impede US vaccination efforts.

In his public comments, Johnson was relaying the findings of an expert body advising his government, the New and Emerging Respiratory Virus Threats Advisory Group, whose assessment was somewhat less alarmist than the prime minister’s version. 

It said the variant’s success at spreading exponentially during a national lockdown period gave the group “moderate confidence” that it “demonstrates a substantial increase in transmissibility compared to other variants.”

The situation could prove to be a false alarm. Sometimes virus variants appear to seem to spread more easily but in fact are being propelled by luck, like a superspreader event. 

British teams, and some abroad, are now racing to carry out the lab experiments necessary to demonstrate whether the new variant really infects human cells more easily, and whether vaccines will stop it; those studies will involve exposing the new strain to blood plasma from covid-19 survivors or vaccinated people, to see if their antibodies can block it. 

Viruses frequently mutate or develop small changes in their genetic code. Since the start of the pandemic, scientists sequencing samples of the coronavirus have been tracking those changes to gain insight into how, and where, the pathogen has been spreading. 

One reason the mutated virus was spotted in the UK might be that the country has pursued such “genomic epidemiology” aggressively. For example, British labs contributed fully 45% of the 275,000 coronavirus sequences deposited to the global GISAID database, according to a threat assessment brief from the European Centre for Disease Prevention and Control.  

According to the COVID-19 Genomics Consortium UK, the coalition of labs that’s been sequencing viruses, the variant’s earliest appearance is in a sample collected September 20 in Kent and one a day later in London. 

Distinct signature

While mutations in the coronavirus are seen all the time, the new variant raised alarms because it appeared at the same time as a sharp increase in cases in the southeast of England, where the infection rate has recently quadrupled. About half those cases were found to be caused by the new variant. 

The genetic code of the variant also caught scientists’ attention because of how much it differed from the original version. According to a preliminary characterizations posted to the website virological.org by the COVID-19 Genomics Consortium UK, the variant possesses a “distinct” genetic signature featuring “an unusually large number of genetic changes,” particularly in its spike protein, which are more likely to alter its function.

The mutations seen in the new variant have all been spotted previously, according to comments posted online by Francois Balloux, a computational biologist at the University of College London, but apparently not in this combination. They include one that causes the spike protein to bind more effectively to human cells, another linked to escape from human immune responses, and a third adjacent to a biologically critical component of the pathogen. 

During this pandemic, spreading variants of the virus have tended to pick up one or two new mutations a month. The UK scientists say they were surprised to find a variant that has accumulated a unique pattern of more than a dozen changes to important genes, which they suggested were clues the strain might be the result of evolutionary adaptation.

Dodging the immune response?

In the UK’s group preliminary report, Andrew Rambaut, a biologist at the University of Edinburgh, and his colleagues say they think the variant might have evolved inside a person who is immunocompromised and who became chronically infected with the coronavirus. Such people, in some cases, have been given multiple rounds of treatment with antibody and antiviral drugs. That could select for viruses that survive such treatment.

If the changed virus is able to “evade” the usual immune response, that may also explain why it’s spreading faster, since it would also affect some covid-19 survivors and therefore have more hosts to infect. According to the British scientific reports, four of about 1,000 people infected by the new variant previously had covid-19, although the scientists were not able to say if that figure was out of the ordinary. 

It would not come as a total surprise to learn the covid-19 virus is evolving enough to infect people a second time, despite immunity to the original germ. Other coronaviruses, like those that cause the common cold, are known to reinfect people frequently, possibly because of such shape-shifting.

Another way viruses can change significantly is if they establish themselves in another species—even zoo tigers can catch covid—and then jump back to people. That was seen in Denmark, which this fall  reported transmission of the covid virus between humans and mink and back again, a situation deemed so dangerous that the country ordered all the mink on commercial fur farms to be culled. 

Now the world will learn if it’s possible to stop the new variant from spreading. That won’t be easy. The existing forms of covid-19 are already transmitting quickly despite social distancing and masks. If the new variant is really 70% more easily spread, it could soon become the dominant form of the disease. 

British authorities over the weekend faced some criticism that they were raising alarms over the new strain to justify strict lockdown measures before Christmas, including stay-at-home orders for millions of people. But officials took to the air to encourage people to abide by the restrictions. “The new variant is out of control and we need to bring it under control,” Matt Hancock, the health secretary, told the BBC. He urged his countrymen to “act like you have the virus.” 

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