Ice Lounge Media

Ice Lounge Media

Last year, China saw a boom in foundation models, the do-everything large language models that underpin the AI revolution. This year, the focus has shifted to AI agents—systems that are less about responding to users’ queries and more about autonomously accomplishing things for them. 

There are now a host of Chinese startups building these general-purpose digital tools, which can answer emails, browse the internet to plan vacations, and even design an interactive website. Many of these have emerged in just the last two months, following in the footsteps of Manus—a general AI agent that sparked weeks of social media frenzy for invite codes after its limited-release launch in early March

These emerging AI agents aren’t large language models themselves. Instead, they’re built on top of them, using a workflow-based structure designed to get things done. A lot of these systems also introduce a different way of interacting with AI. Rather than just chatting back and forth with users, they are optimized for managing and executing multistep tasks—booking flights, managing schedules, conducting research—by using external tools and remembering instructions. 

China could take the lead on building these kinds of agents. The country’s tightly integrated app ecosystems, rapid product cycles, and digitally fluent user base could provide a favorable environment for embedding AI into daily life. 

For now, its leading AI agent startups are focusing their attention on the global market, because the best Western models don’t operate inside China’s firewalls. But that could change soon: Tech giants like ByteDance and Tencent are preparing their own AI agents that could bake automation directly into their native super-apps, pulling data from their vast ecosystem of programs that dominate many aspects of daily life in the country. 

As the race to define what a useful AI agent looks like unfolds, a mix of ambitious startups and entrenched tech giants are now testing how these tools might actually work in practice—and for whom.

Set the standard

It’s been a whirlwind few months for Manus, which was developed by the Wuhan-based startup Butterfly Effect. The company raised $75 million in a funding round led by the US venture capital firm Benchmark, took the product on an ambitious global roadshow, and hired dozens of new employees. 

Even before registration opened to the public in May, Manus had become a reference point for what a broad, consumer‑oriented AI agent should accomplish. Rather than handling narrow chores for businesses, this “general” agent is designed to be able to help with everyday tasks like trip planning, stock comparison, or your kid’s school project. 

Unlike previous AI agents, Manus uses a browser-based sandbox that lets users supervise the agent like an intern, watching in real time as it scrolls through web pages, reads articles, or codes actions. It also proactively asks clarifying questions, supports long-term memory that would serve as context for future tasks.

“Manus represents a promising product experience for AI agents,” says Ang Li, cofounder and CEO of Simular, a startup based in Palo Alto, California, that’s building computer use agents, AI agents that control a virtual computer. “I believe Chinese startups have a huge advantage when it comes to designing consumer products, thanks to cutthroat domestic competition that leads to fast execution and greater attention to product details.”

In the case of Manus, the competition is moving fast. Two of the most buzzy follow‑ups, Genspark and Flowith, for example, are already boasting benchmark scores that match or edge past Manus’s. 

Genspark, led by former Baidu executives Eric Jing and Kay Zhu, links many small “super agents” through what it calls multi‑component prompting. The agent can switch among several large language models, accepts both images and text, and carries out tasks from making slide decks to placing phone calls. Whereas Manus relies heavily on Browser Use, a popular open-source product that lets agents operate a web browser in a virtual window like a human, Genspark directly integrates with a wide array of tools and APIs. Launched in April, the company says that it already has over 5 million users and over $36 million in yearly revenue.

Flowith, the work of a young team that first grabbed public attention in April 2025 at a developer event hosted by the popular social media app Xiaohongshu, takes a different tack. Marketed as an “infinite agent,” it opens on a blank canvas where each question becomes a node on a branching map. Users can backtrack, take new branches, and store results in personal or sharable “knowledge gardens”—a design that feels more like project management software (think Notion) than a typical chat interface. Every inquiry or task builds its own mind-map-like graph, encouraging a more nonlinear and creative interaction with AI. Flowith’s core agent, NEO, runs in the cloud and can perform scheduled tasks like sending emails and compiling files. The founders want the app to be a “knowledge marketbase”, and aims to tap into the social aspect of AI with the aspiration of becoming “the OnlyFans of AI knowledge creators”.

What they also share with Manus is the global ambition. Both Genspark and Flowith have stated that their primary focus is the international market.

A global address

Startups like Manus, Genspark, and Flowith—though founded by Chinese entrepreneurs—could blend seamlessly into the global tech scene and compete effectively abroad. Founders, investors, and analysts that MIT Technology Review has spoken to believe Chinese companies are moving fast, executing well, and quickly coming up with new products. 

Money reinforces the pull to launch overseas. Customers there pay more, and there are plenty to go around. “You can price in USD, and with the exchange rate that’s a sevenfold multiplier,” Manus cofounder Xiao Hong quipped on a podcast. “Even if we’re only operating at 10% power because of cultural differences overseas, we’ll still make more than in China.”

But creating the same functionality in China is a challenge. Major US AI companies including OpenAI and Anthropic have opted out of mainland China because of geopolitical risks and challenges with regulatory compliance. Their absence initially created a black market as users resorted to VPNs and third-party mirrors to access tools like ChatGPT and Claude. That vacuum has since been filled by a new wave of Chinese chatbots—DeepSeek, Doubao, Kimi—but the appetite for foreign models hasn’t gone away. 

Manus, for example, uses Anthropic’s Claude Sonnet—widely considered the top model for agentic tasks. Manus cofounder Zhang Tao has repeatedly praised Claude’s ability to juggle tools, remember contexts, and hold multi‑round conversations—all crucial for turning chatty software into an effective executive assistant.

But the company’s use of Sonnet has made its agent functionally unusable inside China without a VPN. If you open Manus from a mainland IP address, you’ll see a notice explaining that the team is “working on integrating Qwen’s model,” a special local version that is built on top of Alibaba’s open-source model. 

An engineer overseeing ByteDance’s work on developing an agent, who spoke to MIT Technology Review anonymously to avoid sanction, said that the absence of Claude Sonnet models “limits everything we do in China.” DeepSeek’s open models, he added, still hallucinate too often and lack training on real‑world workflows. Developers we spoke with rank Alibaba’s Qwen series as the best domestic alternative, yet most say that switching to Qwen knocks performance down a notch.

Jiaxin Pei, a postdoctoral researcher at Stanford’s Institute for Human‑Centered AI, thinks that gap will close: “Building agentic capabilities in base LLMs has become a key focus for many LLM builders, and once people realize the value of this, it will only be a matter of time.”

For now, Manus is doubling down on audiences it can already serve. In a written response, the company said its “primary focus is overseas expansion,” noting that new offices in San Francisco, Singapore, and Tokyo have opened in the past month.

A super‑app approach

Although the concept of AI agents is still relatively new, the consumer-facing AI app market in China is already crowded with major tech players. DeepSeek remains the most widely used, while ByteDance’s Doubao and Moonshot’s Kimi have also become household names. However, most of these apps are still optimized for chat and entertainment rather than task execution. This gap in the local market has pushed China’s big tech firms to roll out their own user-facing agents, though early versions remain uneven in quality and rough around the edges. 

ByteDance is testing Coze Space, an AI agent based on its own Doubao model family that lets users toggle between “plan” and “execute” modes, so they can either directly guide the agent’s actions or step back and watch it work autonomously. It connects up to 14 popular apps, including GitHub, Notion, and the company’s own Lark office suite. Early reviews say the tool can feel clunky and has a high failure rate, but it clearly aims to match what Manus offers.

Meanwhile, Zhipu AI has released a free agent called AutoGLM Rumination, built on its proprietary ChatGLM models. Shanghai‑based Minimax has launched Minimax Agent. Both products look almost identical to Manus and demo basic tasks such as building a simple website, planning a trip, making a small Flash game, or running quick data analysis.

Despite the limited usability of most general AI agents launched within China, big companies have plans to change that. During a May 15 earnings call, Tencent president Liu Zhiping teased an agent that would weave automation directly into China’s most ubiquitous app, WeChat. 

Considered the original super-app, WeChat already handles messaging, mobile payments, news, and millions of mini‑programs that act like embedded apps. These programs give Tencent, its developer, access to data from millions of services that pervade everyday life in China, an advantage most competitors can only envy.

Historically, China’s consumer internet has splintered into competing walled gardens—share a Taobao link in WeChat and it resolves as plaintext, not a preview card. Unlike the more interoperable Western internet, China’s tech giants have long resisted integration with one another, choosing to wage platform war at the expense of a seamless user experience.

But the use of mini‑programs has given WeChat unprecedented reach across services that once resisted interoperability, from gym bookings to grocery orders. An agent able to roam that ecosystem could bypass the integration headaches dogging independent startups.

Alibaba, the e-commerce giant behind the Qwen model series, has been a front-runner in China’s AI race but has been slower to release consumer-facing products. Even though Qwen was the most downloaded open-source model on Hugging Face in 2024, it didn’t power a dedicated chatbot app until early 2025. In March, Alibaba rebranded its cloud storage and search app Quark into an all-in-one AI search tool. By June, Quark had introduced DeepResearch—a new mode that marks its most agent-like effort to date. 

ByteDance and Alibaba did not reply to MIT Technology Review’s request for comments.

“Historically, Chinese tech products tend to pursue the all-in-one, super-app approach, and the latest Chinese AI agents reflect just that,” says Li of Simular, who previously worked at Google DeepMind on AI-enabled work automation. “In contrast, AI agents in the US are more focused on serving specific verticals.”

Pei, the researcher at Stanford, says that existing tech giants could have a huge advantage in bringing the vision of general AI agents to life—especially those with built-in integration across services. “The customer-facing AI agent market is still very early, with tons of problems like authentication and liability,” he says. “But companies that already operate across a wide range of services have a natural advantage in deploying agents at scale.”

Read more

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Crypto billionaire Brian Armstrong is ready to invest in CRISPR baby tech

Brian Armstrong, the billionaire CEO of the cryptocurrency exchange Coinbase, says he’s ready to fund a US startup focused on gene-editing human embryos. If he goes forward, it would be the first major commercial investment in one of medicine’s most fraught ideas.

In a post on X June 2, Armstrong announced he was looking for gene-editing scientists and bioinformatics specialists to form a founding team for an “embryo editing” effort targeting an unmet medical need, such as a genetic disease.

The announcement from a deep-pocketed backer is a striking shift for a field considered taboo following the 2018 birth of the world’s first genetically edited children in China—a secretive experiment that led to international outrage and prison time for the lead scientist. Read the full story.

—Antonio Regalado

Over $1 billion in federal funding got slashed for this polluting industry

The clean cement industry might be facing the end of the road, before it ever really got rolling. 

Last week, the US Department of Energy announced that it was canceling $3.7 billion in funding for 24 projects related to energy and industry. That included nearly $1.3 billion for cement-related projects.

Cement is a massive climate problem, accounting for roughly 7% of global greenhouse-gas emissions. What’s more, it’s a difficult industry to clean up, with huge traditional players and expensive equipment and infrastructure to replace. This funding was supposed to help address those difficulties, by supporting projects on the cusp of commercialization. Now companies will need to fill in the gap left by these cancellations, and it’s a big one. Read the full story.

—Casey Crownhart

This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here.

MIT Technology Review Narrated: How DeepSeek became a fortune teller for China’s youth

AI-powered BaZi analysis has become the new oracle for a disillusioned generation seeking answers.

This is our latest story to be turned into a MIT Technology Review Narrated podcast, which 
we’re publishing each week on Spotify and Apple Podcasts. Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as it’s released.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Reddit is suing Anthropic 
Reddit claims the AI company kept accessing its site after claiming it had stopped. (WSJ $)
+ Reddit says AI companies should not scrape the web without limitations. (NYT $)
+ It claims that other AI giants have played by its rules. (NBC News)

2 Inside the rise and rise of deepfake scams
The best way to protect yourself is to back up and think who (or what) you’re trusting. (Wired $)
+ An AI startup made a hyperrealistic deepfake of me that’s so good it’s scary. (MIT Technology Review)

3 A lawsuit accuses DOGE of exploiting “error-riden” data to fire workers
It claims the department knew its records were inaccurate, but used them to fire 10,000 employees anyway.(Ars Technica)
+ Unlike Elon Musk, Russ Vought knows the federal government inside out. (NY Mag $)
+ The first wave of DOGE staffers are becoming full-time government workers. (Wired $)
+ DOGE’s tech takeover threatens the safety and stability of our critical data. (MIT Technology Review)

4 Can we make AI behave how we want it to?
Looking all the way back to Asimov’s Laws can offer us some clues. (New Yorker $)

5 Abuse is rife in Taiwan’s semiconductor factories
Workers were threatened with deportation and regular 16-hour shifts. (Rest of World)
+ The Trump administration is renegotiating chip grants, apparently. (Reuters)

6 Amazon wants to use humanoid robots to deliver packages
It’s planning to test its bipedal machines’ ability to tackle an obstacle course.(The Information $)
+ Why the humanoid workforce is running late. (MIT Technology Review)

7 We don’t know how to archive the digital age properly
Historians worry that they may lose access to intimate materials. (The Atlantic $)
+ The race to save our online lives from a digital dark age. (MIT Technology Review)

8 Here’s how major AI helpers tackled a rigorous reading test
Bearing in mind, they all still hallucinated. (WP $)

9 Christians really love AI slop
A major Christian media company is using new tools to spread the word. (404 Media)
+ AI-generated garbage will make ads creepier and worse. (Bloomberg $)
+ It’s also warping media metrics beyond recognition. (Digiday)

10 What we can learn from potty-mouthed robots 🤬
A lot of people swear. Why shouldn’t robots, too? (IEEE Spectrum)

Quote of the day

“Anthropic bills itself as the white knight of the AI industry. It is anything but.” 

—Reddit takes aim at Anthropic in a legal filing against the AI company, the Verge reports.

One more thing

Maybe you will be able to live past 122

How long can humans live? This is a good time to ask the question. The longevity scene is having a moment, and research suggests that we might be able to push human life spans further, potentially even reversing some signs of aging.

Researchers can’t even agree on what the exact mechanisms of aging are and which they should be targeting. Debates continue to rage over how long it’s possible for humans to live—and whether there is a limit at all.

But it looks likely that something will be developed in the coming decades that will help us live longer, in better health. Read the full story.

—Jessica Hamzelou

We can still have nice things

A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line or skeet ’em at me.)

+ There’s something so uplifting about this user-generated collection of videos of parks. 
+ I could get on board with living in a cabin in the woods if it was this one
+ You should probably let go of that grudge you’re holding onto. 
+ Looking for some seasonal recipe inspo? Look no further.

Read more

The clean cement industry might be facing the end of the road, before it ever really got rolling. 

On Friday, the US Department of Energy announced that it was canceling $3.7 billion in funding for 24 projects related to energy and industry. That included nearly $1.3 billion for cement-related projects.

Cement is a massive climate problem, accounting for roughly 7% of global greenhouse-gas emissions. What’s more, it’s a difficult industry to clean up, with huge traditional players and expensive equipment and infrastructure to replace. This funding was supposed to help address those difficulties, by supporting projects on the cusp of commercialization. Now companies will need to fill in the gap left by these cancellations, and it’s a big one. 

First up on the list for cuts is Sublime Systems, a company you’re probably familiar with if you’ve been reading this newsletter for a while. I did a deep dive last year, and the company was on our list of Climate Tech Companies to Watch in both 2023 and 2024.

The startup’s approach is to make cement using electricity. The conventional process requires high temperatures typically achieved by burning fossil fuels, so avoiding that could prevent a lot of emissions. 

In 2024, Sublime received an $87 million grant from the DOE to construct a commercial demonstration plant in Holyoke, Massachusetts. That grant would have covered roughly half the construction costs for the facility, which is scheduled to open in 2026 and produce up to 30,000 metric tons of cement each year. 

“We were certainly surprised and disappointed about the development,” says Joe Hicken, Sublime’s senior VP of business development and policy. Customers are excited by the company’s technology, Hicken adds, pointing to Sublime’s recently announced deal with Microsoft, which plans to buy up to 622,500 metric tons of cement from the company. 

Another big name, Brimstone, also saw its funding affected. That award totaled $189 million for a commercial demonstration plant, which was expected to produce over 100,000 metric tons of cement annually. 

In a statement, a Brimstone representative said the company believes the cancellation was a “misunderstanding.” The statement pointed out that the planned facility would make not only cement but also alumina, supporting US-based aluminum production. (Aluminum is classified as a critical mineral by the US Geological Survey, meaning it’s considered crucial to the US economy and national security.) 

An award to Heidelberg Materials for up to $500 million for a planned Indiana facility was also axed. The idea there was to integrate carbon capture and storage to clean up emissions from the plant, which would have made it the first cement plant in the US to demonstrate that technology. In a written statement, a representative said the decision can be appealed, and the company is considering that option.

And National Cement’s funding for the Lebec Net-Zero Project, another $500 million award, was canceled. That facility planned to make carbon-neutral cement through a combination of strategies: reducing the polluting ingredients needed, using alternative fuels like biomass, and capturing the plant’s remaining emissions. 

“We want to emphasize that this project will expand domestic manufacturing capacity for a critical industrial sector, while also integrating new technologies to keep American cement competitive,” said a company spokesperson in a written statement. 

There’s a sentiment here that’s echoed in all the responses I received: While these awards were designed to cut emissions, these companies argue that they can fit into the new administration’s priorities. They’re emphasizing phrases like “critical minerals,” “American jobs,” and “domestic supply chains.” 

“We’ve heard loud and clear from the Trump administration the desire to displace foreign imports of things that can be made here in America,” Sublime’s Hicken says. “At the end of the day, what we deliver is what the policymakers in DC are looking for.” 

But this administration is showing that it’s not supporting climate efforts—often even those that also advance its stated goals of energy abundance and American competitiveness. 

On Monday, my colleague James Temple published a new story about cuts to climate research, including tens of millions of dollars in grants from the National Science Foundation. Researchers at Harvard were particularly hard hit. 

Even as there’s interest in advancing the position of the US on the world’s stage, these cuts are making it hard for researchers and companies alike to do the crucial work of understanding our climate and developing and deploying new technologies. 

This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here.

Read more

Brian Armstrong, the billionaire CEO of the cryptocurrency exchange Coinbase, says he’s ready to fund a US startup focused on gene-editing human embryos. If he goes forward, it would be the first major commercial investment in one of medicine’s most fraught ideas.

In a post on X June 2, Armstrong announced he was looking for gene-editing scientists and bioinformatics specialists to form a founding team for an “embryo editing” effort targeting an unmet medical need, such as a genetic disease.

“I think the time is right for the defining company in the US to be built in this area,” Armstrong posted. 

The announcement from a deep-pocketed backer is a striking shift for a field considered taboo following the 2018 birth of the world’s first genetically edited children in China—a secretive experiment that led to international outrage and prison time for the lead scientist.

According to Dieter Egli, a gene-editing scientist at Columbia University whose team has briefed Armstrong, his plans may be motivated in part by recent improvements in editing technology that have opened up a safer, more precise way to change the DNA of embryos.

That technique, called base editing, can deftly change a single DNA letter. Earlier methods, on the other hand, actually cut the double helix, damaging it and causing whole genes to disappear. “We know much better now what to do,” says Egli. “It doesn’t mean the work is all done, but it’s a very different game now—entirely different.”  

Shoestring budget

Embryo editing, which ultimately aims to produce humans with genes tailored by design, is an idea that has been heavily stigmatized and starved of funding. While it’s legal to study embryos in the lab, actually producing a gene-edited baby is flatly illegal in most countries.

In the US, the CRISPR baby ban operates via a law that forbids the Food and Drug Administration from considering, or even acknowledging, any application it gets to attempt a gene-edited baby. But that rule could be changed, especially if scientists can demonstrate a compelling use of the technique—or perhaps if a billionaire lobbies for it.

In his post, Armstrong included an image of a seven-year-old Pew Research Center poll showing Americans were strongly favorable to altering a baby’s genes if it could treat disease, although the same poll found most opposed experimentation on embryos.  

Up until this point, no US company has openly pursued embryo editing, and the federal government doesn’t fund studies on embryos at all. Instead, research on gene editing in embryos has been carried forward in the US by just two academic centers, Egli’s and one at the Oregon Health & Science University.

Those efforts have operated on a shoestring, held together by private grants and university funds. Researchers at those centers said they support the idea of a well-financed company that could advance the technology. “We would honestly welcome that,” says Paula Amato, a fertility doctor at Oregon Health & Science University and the past president of the American Society for Reproductive Medicine. 

“More research is needed, and that takes people and money,” she says, adding that she doesn’t mind if it comes from “tech bros.”

Editing embryos can, in theory, be used to correct genetic errors likely to cause serious childhood conditions. But since in most cases genetic testing of embryos can also be used to avoid those errors, many argue it will be hard to find a true unmet need where the DNA-altering technique is actually necessary.

Instead, it’s easy to conclude that the bigger market for the technology would be to intervene in embryos in ways that could make humans resistant to common conditions, such as heart disease or Alzheimer’s. But that is more controversial because it’s a type of enhancement, and the changes would also be passed through the generations.

Only last week, several biotech trade and academic groups demanded a 10-year moratorium on heritable human genome editing, saying the technology has few real medical uses and “introduces long-term risks with unknown consequences.”

They said the ability to “program” desired traits or eliminate bad ones risked a new form of “eugenics,” one that would have the effect of “potentially altering the course of evolution.”

No limits

Armstrong did not reply to an email from MIT Technology Review seeking comment about his plans. Nor did his company Coinbase, a cryptocurrency trading platform that went public in 2021 and is the source of his fortune, estimated at $10 billion by Forbes.

The billionaire is already part of a wave of tech entrepreneurs who’ve made a splash in science and biology by laying down outsize investments, sometimes in far-out ideas. Armstrong previously cofounded NewLimit, which Bloomberg calls a “life extension venture” and which this year raised a further $130 million to explore methods to reprogram old cells into an embryonic-like state.

He started that company with Blake Byers, an investor who has said a significant portion of global GDP should be spent on “immortality” research, including biotech approaches and ways of uploading human minds to computers.

Then, starting late last year, Armstrong began publicly telegraphing his interest in exploring a new venture, this time connected to assisted reproduction. In December, he announced on X that he and Byers were ready to meet with entrepreneurs working on “artificial wombs,” “embryo editing,” and “next-gen IVF.”

The post invited people to apply to attend an off-the-record dinner—a kind of forbidden-technologies soiree. Applicants had to fill in a Google form answering a few questions, including “What is something awesome you’ve built?”

Among those who attended the dinner was a postdoctoral fellow from Egli’s lab, Stepan Jerabek, who has been testing base-editing in embryos. Another attendee, Lucas Harrington, is a gene-editing scientist who trained at the University of California, Berkeley under Jennifer Doudna, a winner of the Nobel Prize in chemistry for development of CRISPR gene editing. Harrington says a venture group he helps run, called SciFounders, is also considering starting an embryo-editing company.

“We share an interest in there being a company to empirically evaluate whether embryo editing can be done safely, and are actively exploring incubating a company to undertake this,” Harrington said in an email. “We believe there need to be legitimate scientists and clinicians working to safely evaluate this technology.”

Because of how rapidly gene editing is advancing, Harrington has also criticized bans and moratoria on the technology. These can’t stop it from being applied but, he says, can drive it into “the shadows,” where it might be used less safely. According to Harrington, “several biohacker groups have quietly raised small amounts of capital” to pursue the technology.

By contrast, Armstrong’s public declaration on X represents a more transparent approach. “It seems pretty serious now. They want to put something together,” says Egli, who hopes the Coinbase CEO might fund some research at his lab. “I think it’s very good he posted publicly, because you can feel the temperature, see what reaction you get, and you stimulate the public conversation.”

Editing error

The first reports that researchers were testing CRISPR on human embryos in the lab emerged from China in 2015, causing shock waves as it became clear how easy, in theory, it was to change human heredity. Two years later, in 2017, a report from Oregon claimed successful correction of a dangerous DNA mutation present in lab embryos made from patients’ egg and sperm cells.

But that breakthrough was not what it seemed. More careful testing by Egli and others showed that CRISPR technology actually can cause havoc in a cell, often deleting large chunks of chromosomes. That’s in addition to mosaicism, in which edits occur differently in different cells. What looked at first like precise DNA editing was in fact a dangerous process causing unseen damage.

While the public debate turned on the ethics of CRISPR babies—especially after three edited children were born in China—researchers were discussing basic scientific problems and how to solve them.

Since then, both US labs, as well as some in China, have switched to base editing. That method causes fewer unexpected effects and, in theory, could also endow an embryo with a number of advantageous gene variants, not just one change.

Company job

Some researchers also feel certain that editing an embryo is simpler than trying to treat sick adults. The only approved gene-editing treatment, for sickle-cell disease, costs more than $2 million. By contrast, editing an embryo could be incredibly cheap, and if it’s done early, when an embryo is forming, all the body cells could carry the change.

“You fix the text before you print the book,” says Egli. “It seems like a no-brainer.”

Still, gene editing isn’t quite ready for prime time in making babies. Getting there requires more work, including careful design of the editing system (which includes a protein and short guide molecule) and systematic ways to check embryos for unwanted DNA changes. That is the type of industrial effort Armstrong’s company, if he funds one, would be suited to carry out.

“You would have to optimize something to a point where it is perfect, to where it’s a breeze,” says Egli. “This is the kind of work that companies do.”

Read more
1 14 15 16 17 18 2,725